STABLE AQUEOUS COMPOSITIONS OF PROTEIN MIA/CD-RAP Russian patent published in 2016 - IPC C07K14/78 A61K38/17 A61P19/02 A61P19/04 

Abstract RU 2588658 C2

FIELD: biochemistry.

SUBSTANCE: present invention relates to biochemistry and more particularly to stable aqueous compositions comprising from about 5 to 30 mg / ml protein CD-RAP and charged amino acid having a net charge at pH of about 6 to 8, and a kit for cartilage repair comprising said composition and instructions for use. Present invention allows to obtain stable aqueous compositions CD-RAP protein, said protein comprising a high concentration, which at the same time reduced the aggregation of polypeptides of CD-RAP over a long period of time and with repeated cycles of freezing and thawing.

EFFECT: composition of the present invention is for use in the treatment of inflammatory disorders, preferably osteoarthritis.

10 cl, 11 dwg, 5 tbl, 8 ex

Similar patents RU2588658C2

Title Year Author Number
STABLE AQUEOUS PROTEIN COMPOSITIONS OF MIA/CD-RAP 2011
  • Hellerbrand Klaus
  • Sigl Rainer
RU2739078C2
DRIED RECONSTITUTED VESICLES FOR PHARMACEUTICAL APPLICATION 2007
  • Khellerbrand Klaus
  • Shutts Andreas
  • Sigl Rajner
RU2443412C2
ALTERNATIVE COMPOSITIONS FOR TNFR:FC CHIMERICAL POLYPEPTIDES 2014
  • Banado Karlos
  • Rakha Tamal
  • Bes Sedrik
RU2663727C2
STABLE LIQUID ETANERCEPT COMPOSITION 2012
  • Choi Suk Young
  • Ko Youn Kyung
  • So Jin Eon
RU2575619C2
FORMULATIONS OF SINGLE DOMAIN ANTIGEN BINDING MOLECULES 2013
  • Fernandes Dzhejson E.
  • Dikson Deniel A.
  • Paulson Andrea
RU2683861C2
LIQUID COMPOSITION OF AN ANTIBODY AGAINST TNF ALPHA 2018
  • Yun Sora
  • Ko En Ken
  • So Chzhinon
RU2756619C2
CONCENTRATED PROTEIN PHARMACEUTICAL COMPOSITIONS AND THEIR APPLICATION 2011
  • Chen Trejsi T.
RU2626512C2
METHOD OF CONTROLLING MODIFICATION REACTION OF POLYPEPTIDE 2009
  • Sajergaard,Lars
  • Krarup,Janus
RU2532850C2
PHARMACEUTICAL COMPOSITION CONTAINING PLASMINOGEN, AND USE THEREOF 2015
  • Blackman Davida
  • Plum Stacy
  • Garzon-Rodriguez, William
  • Yu Betty
  • Robitaille Martin
RU2711989C2
PHARMACEUTICAL PREPARATION CONTAINING EGF RECEPTOR ANTIBODY 2004
  • Maler Khanns-Kristian
  • Mjuller Robert
RU2381036C2

RU 2 588 658 C2

Authors

Khellerbrand Klaus

Zigl Rajner

Dates

2016-07-10Published

2011-04-27Filed