FIELD: biochemistry.
SUBSTANCE: present invention relates to biochemistry and more particularly to stable aqueous compositions comprising from about 5 to 30 mg / ml protein CD-RAP and charged amino acid having a net charge at pH of about 6 to 8, and a kit for cartilage repair comprising said composition and instructions for use. Present invention allows to obtain stable aqueous compositions CD-RAP protein, said protein comprising a high concentration, which at the same time reduced the aggregation of polypeptides of CD-RAP over a long period of time and with repeated cycles of freezing and thawing.
EFFECT: composition of the present invention is for use in the treatment of inflammatory disorders, preferably osteoarthritis.
10 cl, 11 dwg, 5 tbl, 8 ex
Title | Year | Author | Number |
---|---|---|---|
STABLE AQUEOUS PROTEIN COMPOSITIONS OF MIA/CD-RAP | 2011 |
|
RU2739078C2 |
DRIED RECONSTITUTED VESICLES FOR PHARMACEUTICAL APPLICATION | 2007 |
|
RU2443412C2 |
ALTERNATIVE COMPOSITIONS FOR TNFR:FC CHIMERICAL POLYPEPTIDES | 2014 |
|
RU2663727C2 |
STABLE LIQUID ETANERCEPT COMPOSITION | 2012 |
|
RU2575619C2 |
FORMULATIONS OF SINGLE DOMAIN ANTIGEN BINDING MOLECULES | 2013 |
|
RU2683861C2 |
LIQUID COMPOSITION OF AN ANTIBODY AGAINST TNF ALPHA | 2018 |
|
RU2756619C2 |
CONCENTRATED PROTEIN PHARMACEUTICAL COMPOSITIONS AND THEIR APPLICATION | 2011 |
|
RU2626512C2 |
METHOD OF CONTROLLING MODIFICATION REACTION OF POLYPEPTIDE | 2009 |
|
RU2532850C2 |
PHARMACEUTICAL COMPOSITION CONTAINING PLASMINOGEN, AND USE THEREOF | 2015 |
|
RU2711989C2 |
PHARMACEUTICAL PREPARATION CONTAINING EGF RECEPTOR ANTIBODY | 2004 |
|
RU2381036C2 |
Authors
Dates
2016-07-10—Published
2011-04-27—Filed