METHOD FOR BIOFIDOBACTERIUM METABOLISM PRODUCTS OBTAINING FOR TREATMENT OF COMBINED RADIATION-THERMAL BODY DAMAGE AND METHOD FOR TREATMENT OF COMBINED RADIATION-THERMAL BODY DAMAGE Russian patent published in 2017 - IPC A61K9/06 A61K9/08 A61K35/16 A61K35/644 A61K35/745 A61P43/00 

FIELD: medicine.

SUBSTANCE: bifidobacteria are grown in 400-500 cm³ flasks with Blaurokk medium for 3-4 days in order to obtain products of their metabolism. The concentration of microbes is determined with standardization of their number to 1×10⁸ CFU/cm. The bifidobacteria mixture with the products of their metabolism in the culture liquid is carefully shaken, poured into 50-100 cm³ centrifuge tube, centrifuged at 5000 rpm for 30 minutes. The resulting supernatant is decanted, the dry matter content is determined and adjusted to 10-15 mg/ml with physiological saline, sterilised by filtration, poured into bottles and stored in a refrigerator at a temperature of 4-6°C. Treatment of combined radiation-thermal body damage includes a 3-fold subcutaneous administration of the anti-ray serum of mammals mixed with metabolic products of bifidobacteria contained in the culture fluid obtained during the bifidobacteria growth in the ratio of 0.5:0.5 at a dose of 18.5-28 mg/kg in terms of protein, with an interval of 24, 48 and 168 hours after radiation-thermal trauma. Then, after 24, 48 and 168 hours, an ointment based on bee products and herbaceous oil is applied to the affected area.

EFFECT: increased effectiveness of treatment of radiation-thermal body damage.

2 cl, 4 tbl, 4 ex