FIELD: pharmacology.
SUBSTANCE: proposed inventions refer to chimerical antigens, vaccine composition, containing such a chimerical antigen, and use of chimerical antigen to obtain vaccines against hepatitis C virus (HCV). Described chimerical anetigen consists of a) the first segment, consisting of area E2 (amino acid 408-540) of HCV poliprotein, b) of the second segment, consisting of area E1 (amino acid 190-222) of HCV poliprotein, and c) of the third segment, consisting of Core area (amino acid 1-50) of this protein, in that order.
EFFECT: strong immune response of a broad spectrum against various antigens of the virus.
14 cl, 25 dwg, 7 ex
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