FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, and concerns an immunostimulating combination for prevention and treatment of hepatitis C. Substance of the invention consists in creation of the immunostimulating combination containing poly I - poly C [poly (I:C)] used as an Toll-like receptor TLR3 agonist, CD40 agonist, a polypeptide which includes protein NS3 of hepatitis C virus, or a fragment of said protein exhibiting ability to CD8+ and CD4+ response induction, and the agonist is chosen from anti-CD40- antibodies, CD40L (natural ligand CD40) and their fragments which keep their ability to bind with CD40. The invention also includes application of said combination for preparing a drug, a pharmaceutical composition, a vaccine, a kit for introduction of the combination and a method for inducing an immune response on hepatitis C virus.
EFFECT: higher clinical effectiveness and lower toxicity.
24 cl, 5 ex, 1 tbl, 5 dwg
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