FIELD: biotechnology.
SUBSTANCE: humanized antibody specific for STEAP-1 and its antigen-binding fragment are proposed. A polynucleotide encoding an antibody or an antigen-binding fragment thereof, a vector, a host cell, a method for anti-STEAP-1 antibody production are described. A method for tumour visualization, a pharmaceutical composition, a medicament for cell proliferative disorder treatment, immunoconjugates and a cysteine-based antibody based on the said antibody are also disclosed.
EFFECT: invention provides new antibodies to STEAP-1 and can be used in medicine.
30 cl, 29 dwg, 2 tbl, 9 ex
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