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2 644 674

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IPC

C12P17/18(2006-01-01)

C07D487/22(2006-01-01)

C12R1/06(2006-01-01)

(21) (22)

Application

2017110009, 2017-03-24

(24)

Start date

2017-03-24

(22)

Actual filing date

2017-03-24

(45)

Published

2018-02-13

(72)

Inventor

Dankova Tatyana VasilevnaMalkov Mark AbovichMalkov Nikita VladimirovichSavelev Evgenij AleksandrovichMishutkin Stanislav Nikolaevich

(73)

Holder

Ooo

METHOD FOR OBTAINING 3,3',3'',3'''-(3,8,13,17-TETRAMETHYLPORPHYRIN-2,7,12,18-TETRAYL) TETRAPROPIONIC ACID (COPROPORPHYRIN) Russian patent published in 2018 - IPC C12P17/18 C07D487/22 C12R1/06

Abstract RU 2644674 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology. Method for obtaining 3,3',3'',3'''- (3,8,13,17-tetramethylporphyrin-2,7,12,18-tetrayl) tetrapropionic acid (copproporphyrin III) from the culture liquid of the biosynthesis process with Arthrobacter strain. Pre-acidified culture liquid is filtered. Copperporphyrin III is precipitated from the resulting solution by adjusting the pH to 3.5 ± 0.5. Then, selective esterification of coproporphyrin with a solution of methyl alcohol in sulfuric acid is carried out with a molar ratio of coproporphyrin: methyl alcohol 1.0÷(20:50). Tetramethyl ester of coproporphyrin is extracted with chloroform. Tetramethyl ester of coproporphyrin is crystallized from the chloroform-methanol solution. Alkaline hydrolysis is carried out in a water-butanol medium with transformation of the tetramethyl ester of coproporphyrin into the free base of coproporphyrin.

EFFECT: invention allows to simplify the technological process of obtaining coproporphyrin III, reduce the consumption of organic solvents.

1 cl, 2 ex

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RU 2 644 674 C1

Authors

Dankova Tatyana Vasilevna

Malkov Mark Abovich

Malkov Nikita Vladimirovich

Savelev Evgenij Aleksandrovich

Mishutkin Stanislav Nikolaevich

Dates

2018-02-13—Published

2017-03-24—Filed