ANTI-RNA VIRAL, INCLUDING ANTI-CORONAVIRUS AGENT - SUBSTITUTED QUINOXALINE, PHARMACEUTICAL COMPOSITION AND APPLICATIONS Russian patent published in 2021 - IPC C07D241/44 C07D405/04 C07H19/02 C07H19/10 C07H19/20 A61K31/498 A61K31/664 A61P31/14 A61P31/16 

Abstract RU 2744429 C1

FIELD: pharmaceutical industry, medicine.

SUBSTANCE: the invention relates to a substituted quinoxaline of general formula 1, where R1 and R2 are optionally the same hydrogen or halogen atoms, R3 is a hydrogen atom, provided that R1, R2 and R3 are not simultaneously hydrogen, or both R1 and R2 are not 6 ,7-dichloro, or if R1 is hydrogen, then R2 is not 7-chloro. The invention also relates to a pharmaceutical composition having the property of an inhibitor of RNA-dependent RNA polymerase (RdRp) of RNA viruses, based on the specified compound of formula 1.

EFFECT: new compounds and pharmaceutical compositions based on them have been obtained, which can be used in medicine as agents that inhibit RNA-dependent RNA polymerase (RdRp) RNA viruses, where the virus is SARS-CoV-2 coronavirus and influenza virus.

5 cl, 1 dwg, 1 tbl, 10 ex

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RU 2 744 429 C1

Authors

Ivashchenko Andrej Aleksandrovich

Ivashchenko Aleksandr Vasilevich

Savchuk Nikolaj Filippovich

Ivashchenko Alena Aleksandrovna

Dates

2021-03-09Published

2020-05-02Filed