FIELD: pharmaceutical industry, medicine.
SUBSTANCE: the invention relates to a substituted quinoxaline of general formula 1, where R1 and R2 are optionally the same hydrogen or halogen atoms, R3 is a hydrogen atom, provided that R1, R2 and R3 are not simultaneously hydrogen, or both R1 and R2 are not 6 ,7-dichloro, or if R1 is hydrogen, then R2 is not 7-chloro. The invention also relates to a pharmaceutical composition having the property of an inhibitor of RNA-dependent RNA polymerase (RdRp) of RNA viruses, based on the specified compound of formula 1.
EFFECT: new compounds and pharmaceutical compositions based on them have been obtained, which can be used in medicine as agents that inhibit RNA-dependent RNA polymerase (RdRp) RNA viruses, where the virus is SARS-CoV-2 coronavirus and influenza virus.
5 cl, 1 dwg, 1 tbl, 10 ex
         
      
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|---|---|---|---|
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 | RU2745985C1 | 
| HEPATITIS B (HBV) INHIBITOR | 2017 | 
 | RU2666727C1 | 
| SUBSTITUTED (2R,3R,5R)-3-HYDROXY-(5-PYRIMIDIN-1-YL)TETRAHYDROFURAN-2-YLMETHYL ARYL PHOSPHORAMIDATES | 2013 | 
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| ANTI-CORONAVIRUS AGENT FOR COVID-19 COMBINATION THERAPY (SARS-COV-2) | 2020 | 
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Authors
Dates
2021-03-09—Published
2020-05-02—Filed