FIELD: chemistry.
SUBSTANCE: invention relates to the chemical-pharmaceutical industry, particularly to a method for producing polysaccharide-containing polymer matrices, which comprises mixing, in a volume ratio of 2:1:2, 30 % acrylamide solution in 1 % methylene bisacrylamide solution, a tris buffer with pH=7.7 and a 1–2 % aqueous polysaccharide solution, adding the resulting solution in a dropwise manner to n-hexane, stirring at a rate of 500 rpm for 1–2 minutes, adding 10 % ammonium persulphate solution to start polymerisation, stirring for 30 minutes, adding a sorbitan monooleate emulsifier while continuing to stir for 15 minutes, then distilling off the n-hexane on a rotary evaporator, distributing the resulting matrices on filter paper, drying, holding in a refrigerator for 48 hours at a temperature of 4–8 °C, washing with chloroform, holding in a desiccator at 4 °C for 100–120 h, wherein said polysaccharide solution used is either an aqueous solution of fucoidan obtained by fractional extraction from brown alga Laminaria saccharina, or an aqueous solution of mannan obtained by separation of yeast autolysate Saccharomyces cerevisiae at a temperature of 45–50 °C for 20–24 hours, or a mixture, in volume ratio of 1:1, of said aqueous solution of fucoidan and said aqueous solution of mannan.
EFFECT: invention enables to obtain polysaccharide-containing matrices with a long shelf life, used to include a wide range of biologically active substances.
1 cl, 3 ex
