AGENT FOR TREATING HUMAN BODY CONDITIONS ASSOCIATED WITH A DECREASE IN THE LEVEL OF EXPRESSION OF THE PROK 1 GENE AND/OR A DECREASE IN THE AMOUNT OF PROKINETICIN 1 PROTEIN ON THE BASIS OF GENE-THERAPEUTIC SUBSTANCES WITH PROK 1 GENE, METHOD FOR OBTAINING AND USING Russian patent published in 2018 - IPC C07K14/475 C12N15/12 C12N15/85 A61K38/18 A61K48/00

Abstract RU 2662944 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, specifically to therapeutic genetic engineering agents, and can be used to correct the pathological human conditions associated with a decrease in the expression of the PROK 1 gene and/or a decrease in the amount of prokineticin 1 protein. Agent comprises a gene therapeutic substance selected from the group of vector plasmids comprising the cDNA of the PROK 1 gene with the prokineticin 1 protein coding sequence with deletions of 5' and 3'-non-translated regions, obtained on from the site of the native unmodified cDNA of the PROK 1 gene or the modified cDNA of the PROK 1 gene.

EFFECT: invention provides a high level of expression of the PROK 1 gene in eukaryotic cells, thereby increasing the amount of prokineticin 1 protein in human cells and/or tissues, in particular in fibroblasts, in endotheliocytes of testicles, adrenals, ovaries and placenta, in vagina, cervix, appendages of uterus, brain regions, cerebellum and pituitary gland.

5 cl, 20 dwg, 18 ex

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RU 2 662 944 C1

Authors

Savelieva Natalia

Dates

2018-07-31—Published

2017-02-17—Filed