FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine and concerns composition of non-invasive application for long-term therapy of chronic pain syndrome and prevents the development of tolerance to analgesic effect of morphine, comprising a core coated with an enteric coating which contains, as an active ingredient, a tridecapeptide H-Tyr-D-Arg-Phe-Gly-(D-Arg)8-Gly-OH*10HCl and as the target auxiliary components, the modified milk sugar and/or dibasic calcium phosphate anhydrous and the stearic acid salt. Group of inventions also relates to process for preparation of said composition.
EFFECT: group of inventions provides a uniform and rapid release profile of the tridecapeptide, high fracture and abrasion resistance, the stability of the active ingredient during storage and a shelf life of more than two years.
12 cl, 5 dwg, 2 tbl, 7 ex
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