FIELD: medicine.
SUBSTANCE: invention relates to experimental medicine, namely to experimental oncology, and can be used to predict tumor growth in an experiment. Method of prediction consists in that white mongrel rats or rats of the Wistar line grafted into the subcutaneous tissue of the pelvic region of the back of the Guerin carcinoma reached a volume of 0.25 cm3, conduct therapeutic chemotherapy. Use cyclophosphamide at a dose of 50 mcg/kg twice with an interval of 5 days in combination with oral administration of 2 drops of 3 times a day 0.01 % cAMP solution. At the stage of effect realization, the level of cAMP is determined in tumor tissue. And at a cAMP level of 0.75±0.2 nmol/l predict tumor regression, and at a cAMP level of 7.03±1.05 nmol/l predict a tumor progression.
EFFECT: method ensures reliability of predicting tumor growth, which is important for assessing the effectiveness of treatment and timely correction of this treatment.
1 cl, 1 tbl, 4 dwg
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Authors
Dates
2018-10-24—Published
2017-08-30—Filed