METHOD OF CORRECTION OF ESTROGEN DEFICIENCY CONDITIONS IN PATIENTS WITH PREMENOPAUSAL PERIOD WITH DIAGNOSIS OF HR-POSITIVE BREAST CANCER DURING FORMATION OF SUSTAINABLE NEUROTIC AND SOMATIC SYMPTOMS IN FORM OF ACUTE STRESS AND MANIFESTATIONS OF POSTOVARIECTOMY SYNDROME Russian patent published in 2018 - IPC A61M16/10 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to oncology, and can be used in the treatment of cancer patients with a diagnosis of HR-positive breast cancer during the formation of stable neurotic and somatic symptoms in the form of acute stress and manifestations of the postovariectomy syndrome at the stages of specialized treatment. For this, patients at the stage of treatment – surgical castration – are subjected to 5 xenontherapy procedures in the morning every other day. First procedure begins with the supplying xenon concentration of 12–14% in the volume of the inhaled xenon-oxygen mixture. Further procedure time and the dose of xenon is changed in accordance with the following dependency: day 1 – 12–14 % – 20 minutes, day 2 – 14–16 % – 17 minutes, day 3 – 16–18 % – 15 minutes, day 4 – 18–20 % – 12 minutes, day 5 – 20–22 % – 10 min. Given concentration of the breathing mix is achieved by the timely dosed introduction of oxygen and xenon into the hermetic breathing circuit. Clinical criterion for the effectiveness of an inhalation procedure is superficial sleep with a decrease in respiration and heart rate relative to the initial data. To complete the procedure, stop the flow of xenon and further increase the rate of oxygen supply. Respiratory circuit is transferred to a half-closed or open circuit. After inhalation, patients are left for 10–15 minutes in a state of superficial sleep.

EFFECT: method provides a harmonious adaptation response of the organism of patients of reproductive age with this pathology at the stages of specialized treatment by conducting a personalized xenon therapy algorithm with productive restoration of neurohumoral and psychosocial status, improvement of the quality of life, formation of a positive attitude towards rehabilitation and subsequent treatment.

1 cl, 1 ex