METHOD OF OBTAINING DIAGNOSTIC INFORMATION ON THE SMELL OF THE SKIN Russian patent published in 2019 - IPC G01N33/483 A61B5/00 

FIELD: medicine.

SUBSTANCE: invention relates to medical diagnostics and can be used to establish changes and characteristics of volatile metabolites secreted by the skin and detected by a set of chemical gas sensors. Method is characterized by the fact that an “electronic nose” gas analyzer is used with a set of four sensors based on piezoquartz resonators (PQR) of bulk acoustic waves with a base oscillation frequency of 10.0 MHz, the electrodes of which are applied sorbents from acetone suspensions of multi-layered carbon nanotubes, potassium fluoride, zirconyl nitrate, hydroxyapatite, for which the defatted piezoquartz resonators are lowered into acetone suspensions and kept for 5 s, remove free solvent for 10 minutes at a temperature of 100 °C, place the resonators with sorbents in the sockets of the device, put on a cylindrical cover with an open entrance, maintain the system for 5 minutes to establish the stability of the initial oscillation frequency of each sensor (F_i⁰, Hz), include a measurement program with a duration of 200 s and tightly press the inside of the forearm to the lid for 80 s, after the time has elapsed, gently remove the hand and continue to record changes in the signals of all sensors until the set time; the program translates the stored signals into “visual fingerprints” of the sensor responses at discrete measurement points and compare them with data from the database corresponding to the normal state of a particular person, the deviation of these data sets by more than 35 % according to automatic evaluation in the program indicates a change in the normal metabolism; decide on the criticality and causes of these changes in the database for typical conditions.

EFFECT: proposed method allows to obtain diagnostic information on skin odor with implicit changes by measuring the composition of a mixture of volatile organic and inorganic compounds with a set of highly sensitive chemical gas sensors with high expressivity, selectivity and minimal economic costs.

1 cl, 1 dwg