FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to medicine and relates to a liquid pharmaceutical composition of a long-acting erythropoietin (EPO) conjugate containing a therapeutically effective amount of a long acting erythropoietin conjugate, wherein the EPO is covalently linked to an immunoglobulin Fc fragment via a non-peptide polymer or peptide linker, mannitol, buffer, salt, and a non-ionic surfactant. Where mannitol is present in concentrations from 3 to 12 % weight / volume, and the liquid composition does not contain neutral amino acids and albumin, and where the buffer is a sodium phosphate based buffer or sodium citrate based buffer.
EFFECT: invention ensures the storage stability of long-acting EPO conjugates even without using neutral amino acids.
18 cl, 11 ex, 3 dwg, 21 tbl
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