FIELD: pharmacology.
SUBSTANCE: group of inventions concerns a liquid composition comprising a combination of long acting insulin in a form in which insulin is bound to the Fc region of immunoglobulin and insulinotropic peptide in a form in which the peptide is bound to the Fc region of immunoglobulin. The composition does not contain albumin, and the stabiliser contains a buffer, sugar alcohol, a nonionic surfactant and an isotonic agent. The method for liquid composition production is also stated.
EFFECT: group of inventions provides excellent storage stability of a composition containing an insulin conjugate and an insulinotropic peptide conjugate at a high concentration without the risk of contracting viruses.
33 cl, 4 ex, 7 tbl, 4 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITION FOR TREATING DIABETES, CONTAINING LONG-ACTING INSULIN CONJUGATE AND LONG-ACTING INSULINOTROPIC PEPTIDE CONJUGATE | 2012 |
|
RU2606840C2 |
| PHARMACEUTICAL COMPOSITION FOR NON-ALCOHOLIC FATTY LIVER DISEASE PREVENTION OR TREATMENT | 2013 |
|
RU2635966C2 |
| LIQUID FORMULATION OF LONG-ACTING INSULIN CONJUGATE | 2013 |
|
RU2670270C2 |
| LIQUID FORMULATION OF LONG-ACTING INSULINOTROPIC PEPTIDE CONJUGATE | 2013 |
|
RU2671576C2 |
| INSULINOTROPIC COMPLEX IN WHICH IMMUNOGLOBULIN FRAGMENT IS USED | 2008 |
|
RU2436589C2 |
| METHOD OF CONTROLLING CONDITIONS FOR SITE-SPECIFIC BINDING OF POLYPEPTIDE AND NON-PEPTIDE POLYMER | 2010 |
|
RU2495881C2 |
| PHARMACEUTICAL COMPOSITION FOR TREATING OBESITY-RELATED DISEASES CONTAINING INSULINOTROPIC PEPTIDE CONJUGATE | 2008 |
|
RU2446816C2 |
| IMPROVED METHOD FOR PHYSIOLOGICALLY ACTIVE POLYPEPTIDE CONJUGATE PRODUCTION | 2013 |
|
RU2639256C2 |
| METHOD FOR PRODUCING PHYSIOLOGICALLY ACTIVE POLYPEPTIDE COMPLEX | 2012 |
|
RU2624129C2 |
| POLYPEPTIDE COMPLEX CONTAINING NON-PEPTIDYL POLYMER, HAVING THREE FUNCTIONAL ENDS | 2009 |
|
RU2483081C2 |
