FILLYGENIN AND GLUCURONIC ACID DERIVATIVE, METHOD FOR PRODUCTION THEREOF AND USE THEREOF Russian patent published in 2019 - IPC C07H15/26 C07H1/08 A61K31/7048 A61P31/16 A61P29/00 

Abstract RU 2684100 C1

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to an antiviral derivative of general formula (I), pharmaceutical compositions based thereon, a method for production thereof, which can be used in the pharmaceutical and medical industry:

, where R1=CnH2n+1, R2=CnH2n+1, R3=H or R1-R2=-CH2-, R3=CnH2n+1; n=1–30. Disclosed method comprises mixing forsythia leaves with water, heating with boiling and extraction to obtain water extract of forsythia; separating water extract of forsythia on a column with macroporous resin; chromatography of eluate from forsythia obtained on column with macroporous resin, on column with silica gel, collection of eluate and its drying.

EFFECT: disclosed are a novel derivative of phillygenin and glucuronic acid, a novel effective method for production thereof, pharmaceutical compositions based thereon for preparing drugs effective for preventing and treating influenza.

10 cl, 3 ex, 9 tbl

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RU 2 684 100 C1

Authors

Fu, Li

Fan, Hongyu

Jiang, Renwu

Zhang, Yu

Wang, Kaiqian

Liu, Zhengxian

Dates

2019-04-04Published

2016-04-07Filed