FIELD: technological processes; chemistry.
SUBSTANCE: invention relates to a process for the chemical synthesis of phyllyrin, which can be used in the chemical industry. Proposed is a method that includes the following steps: (1) dissolution of glycosyl-phyllygenin acceptor and glycosyl donor – 2,3,4,6-tetra-O-acyl-D-glucopyranosyl trichloroacetimidate in an inert gas atmosphere with the addition of a catalyst and a molecular sieve in anhydrous dichloromethane or anhydrous trichloromethane for glycosylation to give tetraacyl-phyllyrin, (2) dissolving tetraacyl-phyllyrin in an organic solvent, adding sodium methoxide to deacylate, adding an acidic pH regulator to adjust pH of the reaction mixture to neutral and performing purification to produce phyllyrin.
EFFECT: new efficient method for the chemical synthesis of phyllyrin is proposed.
6 cl, 5 tbl, 4 ex
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