MEDICINAL COMPOUNDS Russian patent published in 2019 - IPC C07D487/04 C07D487/14 C07D519/00 A61K31/519 A61P35/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a novel compound of formula (I) and a pharmaceutically acceptable salt thereof. In formula (I) R¹ represents a phenyl group substituted with one or more halogen atoms and optionally a methyl group; R² and R³ are independently selected from a group consisting of a hydrogen atom, a deuterium atom, a methyl group and a phenyl group; R⁴ is a hydrogen atom, C₁-C₆-alkyl group, which is optionally deuterated or substituted with a methoxyphenyl group, a phenyl group optionally substituted with a methyl group, C₁-C₆-alkylamino-C₁-C₆-alkyl group, cyclopropyl group or methylpyrazolyl group; or R² is hydrogen and R⁴ and R³ and ring atoms, to which they are attached, taken together, form 5-member heterocycloalkyl group; and R⁵ represents a phenyl group substituted with one or more groups consisting of C₁-C₆-alkyl group optionally substituted with one or more halogen atoms and hydroxyl group, C₁-C₆-alkoxy group, optionally substituted with one or more halogen atoms, amino, C₁-C₆-alkylamino, hydroxy-C₁-C₆-alkyl group, C₁-C₄-alkylamino-C₁-C₆-alkyl group optionally substituted with one or more hydroxyl groups or carbonyl group, an aminosulfonyl group, an alkylimino sulfoxide group, a halogen atom, a cyano group, a pyridinyl group, a pyrazolyl group substituted with a methyl group, a cyclobutyl group, a substituted amino group, 5- to 6-member heterocycloalkyl group, where 5-6 membered heterocycloalkyl group contains in ring 1-2 nitrogen atoms, or a nitrogen atom and an oxygen atom, or a nitrogen atom and a sulfur atom and its dioxide and where 5-6-member heterocycloalkyl group is optionally substituted with one or more C₁-C₄-alkyl groups optionally substituted with one or more halogen atoms, hydroxy-C₁-C₄-alkyl group, C₁-C₄-alkoxy-C₁-C₄-alkyl group, a halogen atom, hydroxycarbonyl-C₁-C₄-alkyl group, C₃-C₄-cycloalkyl group, carbonyl group, substituted C₁-C₄-alkyl, C₀-C₄-alkylamino-C₁-C₄-alkyl group; or R⁵ represents a phenyl group substituted with 7-8-member mono- or bicyclic heterocycloalkyl group containing one or two nitrogen atoms and optionally an oxygen atom in the ring, where 7-8-member mono- or bicyclic heterocycloalkyl group is optionally substituted with C₁-C₄-alkyl group; or R⁵ represents a phenyl group fused with 6-8-member mono- or bicyclic heterocycloalkyl group containing a nitrogen atom and optionally an oxygen atom in a ring which is optionally substituted with C₁-C₄-alkyl group.

EFFECT: compounds have the properties of Wee-1 kinases and can be used to produce a drug for treating or preventing cancer mediated by Mee1 kinase activity.

26 cl, 1 tbl, 191 ex