NOVEL COMPOUNDS Russian patent published in 2019 - IPC A61K31/167 A61K47/02 A61K47/18 

FIELD: chemistry; pharmaceutics.

SUBSTANCE: group of inventions relates to the chemical-pharmaceutical industry and represents a group of pharmaceutical compositions and a method for preparing them for treating or controlling a disease or condition mediated by aquaporin containing 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate (Formula I)

in solid state and one or more pharmaceutically acceptable Bronsted bases, where one or more pharmaceutically acceptable Bronsted bases is a solid substance. Compositions contain <2 % N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide after one week at room temperature and are suitable for dissolving with an aqueous solution to form an injection. Inventions also include a group of sets for treating or controlling diseases or conditions mediated by aquaporin containing compositions described earlier.

EFFECT: group of inventions enables to obtain compositions of 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenyldihydrogen phosphate with improved stability.

82 cl, 10 dwg, 2 tbl, 18 ex