FIELD: chemistry.
SUBSTANCE: invention relates to derivatives of 4-(substituted phenylamino)quinazoline, having the following formula X, in which m is 2, n is 1, every R1 is selected from the group consisting of R5O substituted with (1-4)C alkoxy; R2 represents hydrogen; R3 group is selected from hydrogen; R4 represents (2-4)C alkynyl; R5 represents (1-4)C alkyl; or to pharmaceutically acceptable salts thereof. Invention also relates to a pharmaceutical composition containing these compounds. 
X.
EFFECT: said compounds inhibit receptor tyrosine kinase and may be useful in the treatment of proliferative diseases, such as malignant tumors in mammals.
2 cl, 2 dwg, 2 tbl, 105 ex
| Title |
Year |
Author |
Number |
| DERIVATIVES OF 4-(SUBSTITUTED PHENYLAMINO)-QUINAZOLINE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF INHIBITION OF RECEPTOR TYROSINE KINASE AND PHARMACEUTICAL COMPOSITION |
1996 |
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- Li Dehniehl Arnol'D
|
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1996 |
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|
RU2136683C1 |
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1995 |
|
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0 |
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SU895291A3 |
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1993 |
|
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2018 |
- Grecu Tudor
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2004 |
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1996 |
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| 5-HETEROCYCLO-1,5-BENZODIAZEPINES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS |
1995 |
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RU2152939C1 |
