METHOD OF CONDUCTING CHILDREN WITH HIRSPERFLY DISEASE IN PERIOPERATIVE PERIOD Russian patent published in 2019 - IPC A61K36/64 A61K31/4164 A61K31/545 A61K31/7036 A61P31/04 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to pediatric surgery, and can be used for children with Hirschsprung's disease in perioperative period with antibacterial prevention. Preoperative preparation involves determination of carriers of toxigenic strains C.difficile, for this purpose, admission to the hospital is followed by examination of faeces for toxigenic strains C.difficile. If C.difficile toxins A and B (or A+B) are detected, an antibacterial therapy is prescribed: vancomycin 10 mg/kg for admission 4 times day for 7 days. Simultaneously, a probiotic preparation is administered based on Saccharomyces boulardii 250 mg once day for 7 days. In intraoperative period 60 minutes before the operation, metronidazole 7.5 mg/kg is intravenously administered. 30–40 minutes before the operation intravenous introduction of cefazolin 25 mg/kg. If the surgical intervention is continued for more than 3–4 hours, one more dose of cefazolin is added. Either 120 minutes before the surgical intervention, vancomycin 40 mg/kg is administered. That is followed by intravenous administration of cefazolin 25 mg/kg 30–40 minutes before the operation. If the surgical intervention is continued for more than 3–4 hours, one more dose of cefazolin is added. If observing allergic reactions to beta-lactam antibiotics, a combination of clindamycin 600 mg/kg and gentamycin 5 mg/kg is administered 40–60 minutes prior to surgery. In the presence of infectious complications in the postoperative period, etiotropic antibiotic and a probiotic based on S. boulardii 250 mg once day for 7 days are prescribed. If observing no infectious complications, the antibacterial therapy is not followed, and the S. boulardii-based probiotic is prescribed for 7 days.

EFFECT: invention enables reducing a risk of enterocolitis and other infectious complications and reduces length of stay of the patient in a hospital bed.

1 cl, 2 ex