FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology. Invention represents a C/2014 strain of the Machupo virus - agent of Bolivian haemorrhagic fever (BGL), a version of the Carvallo natural strain adapted to guinea pigs and causing death related to the introduced dose of the virus.
EFFECT: invention enables to determine and calculate values of LD50 for the BGL agent expressed in the PFU (plaque-forming unit), in experiments on model laboratory animals - guinea pigs; calculate the infectious doses expressed in LD50, for guinea pigs when laboratory animals are infected in MCS experimental studies; obtaining statistically reliable information on the effectiveness of the developed MRMs with respect to the BGL agent.
1 cl, 5 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| EBOLA-ZAIRE VIRUS STRAIN ESMS 2020 ADAPTED FOR GUINEA PIGS, INTENDED FOR PRECLINICAL TESTING OF MEDICAL PROTECTIVE MEANS AGAINST EBOLA HEMORRHAGIC FEVER | 2020 |
|
RU2749345C1 |
| VIRUS LASS STRAIN "SVINKA" DESIGNATED FOR LABORATORY EVALUATION OF EFFECTIVENESS OF MEDICINAL PROTECTION AGENTS | 2004 |
|
RU2274655C1 |
| STRAIN OF EBOL VIRUS "ZAIR K-5" FOR CARRYING OUT MODEL EXPERIMENTS AND PREPARING DIAGNOSTIC AND VACCINE PREPARATIONS | 2001 |
|
RU2225439C2 |
| COMPOSITION OF AGAR COATINGS FOR DETERMINING MACHUPO - BOLIVIAN HEMORRHAGIC FEVER VIRUS POPULATION CONCENTRATION AND STRUCTURE WITH USING METHOD OF NEGATIVE COLONIES | 2014 |
|
RU2634868C2 |
| PREPARATION CONTAINING ANTIBODY AGAINST BOLIVIAN HAEMORRAGIC FEVER FROM WHEY OF BLOOD OF HORSES, SOLUTION FOR INTRAMUSCULAR INTRODUCTION | 2007 |
|
RU2342952C1 |
| SMALLPOX VIRAL STRAIN GPA FOR STUDYING EFFICACY OF ANTIVIRAL PREPARATIONS in vivo AND ASSESSING REDUCTION ROUTINES UNDESIRED VACCINE REACTIONS ACCOMPANYING PRIMARY SMALLPOX VACCINATION | 2013 |
|
RU2542400C1 |
| STRAIN OF VIRUS "LASSA" FOR IMMUNOBIOLOGICAL PREPARATIONS PRODUCING | 0 |
|
SU1789560A1 |
| STRAIN OF EBOL VIRUS "ZAIR CH-5" FOR CARRYING OUT MODEL EXPERIMENTS AND PREPARING DIAGNOSTIC AND VACCINE PREPARATIONS | 2001 |
|
RU2225440C2 |
| METHOD FOR DETERMINING ANTIGENIC DIFFERENCES OF ARENAVIRUS GENES OF ARENAVIRIDAE FAMILY | 2018 |
|
RU2729052C2 |
| PROCESS FOR MANUFACTURE OF CONCENTRATES OF VIRUSES THAT PROVOKE HEMORRHAGIC FEVER AND POSSESSING IMMUNOGENIC AND PROTECTIVE ACTIVITY | 1991 |
|
RU2029561C1 |
