FIELD: biotechnologies.
SUBSTANCE: invention relates to the biotechnology. Method includes: (1) biological sample nucleic acid sequencing containing free nucleic acids to obtain sequencing results for a plurality of sequencing data; (2) determining, based on sequencing results, the number of nucleic acid molecules with a length falling within a given range, determining the ratio of free nucleic acids in the biological sample.
EFFECT: disclosed is a method for determining an extracellular nucleic acid fraction in a biological sample.
19 cl, 16 dwg, 8 tbl, 3 ex
| Title | Year | Author | Number |
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| NON-INVASIVE DETECTION OF GENETIC FOETAL ABNORMALITY | 2011 |
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| METHOD FOR NONINVASIVE PRENATAL DIAGNOSTICS OF FETAL ANEUPLOIDY | 2015 |
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| NON-INVASIVE DIAGNOSTIC TECHNIQUE FOR FOETAL ANEUPLOIDY BY SEQUENCE ANALYSIS | 2014 |
|
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| METHOD OF DETERMINING THE SOURCE OF ANEUPLOID CELLS ON THE BLOOD OF A PREGNANT WOMAN | 2016 |
|
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| METHODS AND SYSTEMS FOR DETERMINING WHETHER GENOME IS ABNORMAL | 2011 |
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| DETECTION OF MUTATIONS AND PLOIDY IN CHROMOSOMAL SEGMENTS | 2015 |
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