FIELD: chemistry.
SUBSTANCE: invention relates to a compound of chemical formula (1) or a pharmaceutically acceptable salt thereof, in which X is CH or N; Z is O or S; R1 is phenyl, optionally substituted with one or more substitutes selected from halogen, hydroxy, C1-C5 alkyl, C1-C5 alkoxy, C1-C5 alkylthio, amino, di(C1-C5)alkylamino, cyano, formyl, halogen-C1-C5 alkyl, hydroxy-C1-C5 alkyl, C1-C5 alkoxy C1-C5 alkyl, carbamoyloxyC1-C5 alkyl, C1-C5 alkyl-C(O)O-C1-C5 alkyl, di(C1-C5)alkylamino-C1-C5 alkyl and 5-member heterocyclic1-C5 alkyl, where heterocycloalkyl has 1 heteroatom selected from N; or 9-member unsaturated heterocyclyl, having 2 heteroatoms selected from O, which is optionally substituted with one or more substitutes selected from halogen; 5–10 membered heteroaryl having 1 or 2 heteroatoms selected from N or S, which is optionally substituted with one or more substitutes selected from halogen, hydroxy, C1-C5 alkyl, C1-C5 alkoxy, halogenC1-C5 alkyl and di(C1-C5)alkylamino, and R2 is phenyl, optionally substituted with one or more substitutes selected from halogen, deuterium and hydroxy, or 6–10-member heteroaryl, having 1 or 2 heteroatoms selected from N, which is optionally substituted with one or more substitutes selected from halogen and C1-C5 alkyl. Invention also relates to a pharmaceutical composition for preventing or treating a disorder mediated by dysfunction of glutamate and a metabotropic glutamate receptor of subtype 5 (mGluR5).
EFFECT: technical result is obtaining novel compounds of formula (1), having the properties of a positive allosteric modulator of metabotropic receptor glutamate subtype 5 (mGluR5).
19 cl, 1 tbl, 199 ex
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