FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology, specifically to immunology, and can be used in medicine for anticancer therapy. There are described embodiments of antibodies and their antigen-binding fragments binding with human 4-1BB, also called CD137 or TNFRSF9. There are described embodiments of a pharmaceutical composition for reducing tumor growth or for treating cancer in a subject, as well as methods for reducing tumor growth or treating cancer in a subject, using versions of antibodies or antigen-binding fragments thereof in a therapeutically effective amount. described is a method of treating cancer with using a combination of the antibody and an immunotherapeutic agent.
EFFECT: invention provides preparing new agonist antibodies to human 4-1BB.
14 cl, 8 dwg, 11 tbl, 9 ex
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