FIELD: medicine; cosmetology.
SUBSTANCE: pre-filled plastic syringe comprises an aqueous botulinum toxin composition, a syringe barrel having a proximal end, a distal end and a cylindrical wall extending therebetween, wherein the syringe barrel has a distally projecting cannula with a fluid passage extending therethrough communicating with the cylinder opening; the cylindrical wall has an inner surface coated with a barrier layer; sealing device having an outlet fastening part, which is hermetically connected and closes the distal open outlet end of the syringe, wherein the outlet fastening part is made from an elastomeric material with a coating which is optionally applied on its surface, and a piston rod assembly, which extends into the proximal end of the syringe cylinder and includes a piston seal in the fluid-free sliding joint with the cylindrical clearance of the cylinder opening, wherein the piston sealant is made from an elastomeric material with a coating applied on at least a section of the seal of the piston in contact with the aqueous botulinum toxin composition during storage and/or injection. Elastomer material of outlet fastener is selected from isoprene rubber (IS), butadiene rubber (BR), butyl rubber, halogenated butyl rubber, butadiene-styrene rubber and mixtures thereof, and the elastomer material of the piston sealer is selected from isoprene rubber (IS), butadiene rubber (BR), butyl rubber, halogenated butyl rubber, butadiene-styrene rubber and mixtures thereof, and the barrier barrel of the syringe cylinder is a silicone layer, and the coating on the piston sealer is a cross-linked silicone coating or a fluoropolymer coating. Also disclosed is a kit comprising a pre-filled plastic syringe, versions of using a pre-filled plastic syringe in treatment and for cosmetic use, a method of treating the disease, as well as a method for cosmetic skin treatment.
EFFECT: group of inventions provides stability of an aqueous composition of botulinum toxin for a long time.
13 cl, 4 tbl, 1 dwg
