FIELD: medicine, pharmaceutics.
SUBSTANCE: there is claimed application of concentrated (from 30 mg/mg to 150 mg/ml) methotraxate solution for preparation of medication for subcutaneous introduction for therapy of inflammation-associated autoimmune diseases. Invention also relates to ready for application syringe, carpula, containing said pharmaceutic composition in form of solution, and handle-injector, which contains said carpula and/or ready for application syringe - all contain from 30 mg/mg to 150 mg/ml methotrexate. It is demonstrated that increase of solution concentration to 50 mg/ml reduces volume of daily introduced liquid to 0.6 ml.
EFFECT: there is ensured easier tolerance by patients, which has positive impact on their trust.
32 cl, 2 ex
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