1,3,5-TRIAZINE DERIVATIVE AND A METHOD FOR USE THEREOF Russian patent published in 2020 - IPC C07D401/04 C07D401/12 C07D401/14 A61K31/53 A61P35/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula II, in which X₁ is selected from NH or O, X₂ is N, R₁ is C_1-6 alkyl, where alkyl can be optionally substituted with one or more R₆, R₂ is selected from group, consisting of phenyl, pyridyl, benzyl, C_1-6 alkyl and C_1-6 alkoxy, and can be optionally substituted with one or more R₇, R₃ is C_1-3 haloalkyl, each R₆ is independently selected from a group consisting of hydroxy, C_1-6 alkyl, C_3-6 cycloalkyl and phenyl, each R₇ is independently selected from a group consisting of hydroxy, C_1-3 haloalkyl and C_1-6 alkyl, and n is 0 or 1. Invention also relates to individual compounds, a pharmaceutical composition, a method of treating cancer induced by IDH2 mutation, use of compounds of formula II.

EFFECT: obtaining novel compounds of formula II, having isocitrate dehydrogenase 2 (IDH2) inhibiting activity and capable of treating cancer induced by the IDH2 mutation.

16 cl, 2 tbl, 14 ex