FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to a compound of formula II, in which X1 is selected from NH or O, X2 is N, R1 is C1-6 alkyl, where alkyl can be optionally substituted with one or more R6, R2 is selected from group, consisting of phenyl, pyridyl, benzyl, C1-6 alkyl and C1-6 alkoxy, and can be optionally substituted with one or more R7, R3 is C1-3 haloalkyl, each R6 is independently selected from a group consisting of hydroxy, C1-6 alkyl, C3-6 cycloalkyl and phenyl, each R7 is independently selected from a group consisting of hydroxy, C1-3 haloalkyl and C1-6 alkyl, and n is 0 or 1. Invention also relates to individual compounds, a pharmaceutical composition, a method of treating cancer induced by IDH2 mutation, use of compounds of formula II.
EFFECT: obtaining novel compounds of formula II, having isocitrate dehydrogenase 2 (IDH2) inhibiting activity and capable of treating cancer induced by the IDH2 mutation.
16 cl, 2 tbl, 14 ex
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