COMPOUNDS Russian patent published in 2020 - IPC C07D401/14 C07D403/04 C07D403/14 C07D405/14 C07D413/14 C07D471/04 C07D487/04 C07D491/107 A61K31/4545 A61K31/496 A61K31/506 A61K31/519 A61K31/5377 A61P25/16 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to novel compounds of formula (I) or pharmaceutically acceptable salts thereof

,

where X is selected from CH or N; Y CR₃, and R₃ is methyl; R¹ is selected from a group, consisting of 5- or 6-member heterocyclyl optionally substituted with one, two or three substitutes independently selected from a group consisting of C_1-3 alkyl, optionally further substituted with one C_1-3 alkoxy, C_1-3 alkoxy, halogen, hydroxyl, -SO₂CH₃, -COCH₃, oxo groups, and oxetanyl, -O-4-6-member heterocyclyl, optionally substituted with one or two substituents C_1-3 alkyl, which may be identical or different, and C_1-6 alkoxy; and R² is

,

where Z¹ and Z² independently represent N or CR₇, and where R₇ is H or C_1-3 alkoxy, but Z¹ and Z² can not both be CR₇, R_a is selected from a group consisting of CN, C_1-3 alkyl, C_1-3 alkoxy, -OC_1-3 haloalkyl, and C_3-6 cycloalkyl; and R_b is selected from a group, consisting of 2-oxa-6-azaspiro[3.4]octanyl, C_3-6 cycloalkyl optionally substituted with one hydroxyl, -CONHCH₃, -NHCOCH₃, 4–6-member heterocyclyl, optionally substituted with one or two substituents, independently selected from a group consisting of hydroxyl, CN, -CONHCH₃, oxetanyl, C_1-3 alkyl optionally substituted with one hydroxyl, and C_1-3 alkoxy, optionally substituted with one hydroxyl, which inhibit LRRK2 kinase activity, methods for preparing them, compositions containing them, and their use in treating or preventing diseases, characterized by LRRK2 kinase activity, e.g. Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

EFFECT: compounds can be used in treating or preventing diseases characterized by LRRK2 kinase activity.

15 cl, 273 ex