FIELD: organic chemistry.
SUBSTANCE: invention relates to the field of organic chemistry, namely to a cyclic compound of the formula (I) or to its pharmaceutically acceptable salt, where X is -C(O)NH- or -NHC(O)-; R1 is selected from (C1-C4)alkyl, halogen(C1-C4)alkyl, cyclobutyl, tetrahydrofuranyl, (C1-C4)alkoxy, -N((C1-C3)alkyl)2, -(C1-C3)alkyl-O-(C1-C2)alkyl, -C(O)O(C1-C2)alkyl and cyclopropyl, wherein each of the specified cyclobutyl and cyclopropyl is optionally substituted with C(=O)OMe, -CN or 1 halogen; L2 is CH2 or CHMe; Cy1 is selected from phenyl, pyridyl and piperidinyl, each of which is optionally substituted with 1-2 groups that are independently selected from R5; Cy2 is selected from heterocyclic structures specified in cl. 1, each of which is optionally substituted with 1-2 groups that are independently selected from R6; R5 is selected from halogen, -CN, -ORc, -S(O)2NRdRe and -SO2Rb; R6 is selected from halogen, oxo and (C1-C4)alkyl; R7 is hydrogen, ORc or (C1-C3)alkyl optionally substituted with ORc; R8, if present, is hydrogen; each Rb is independently selected from -NH(C1-C3)alkyl and (C1-C3)alkyl optionally substituted with OH, -C(O)O(C1-C3)alkyl and -C(O)NH(C1-C3)alkyl; each Rc is independently selected from hydrogen and (C1-C3)alkyl, and each Rd and Re are independently selected from hydrogen and (C1-C3)alkyl. The invention also relates to specific compounds of the formula (I), a pharmaceutical composition based on them or the compound of the formula (I), the use of the compound of the specified compounds for the treatment of a disease or disorder mediated by ROR-gamma.
EFFECT: new heterocyclic compounds useful for the treatment of ROR-gamma-mediated disease are obtained.
19 cl, 7 dwg, 10 tbl, 20 ex
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