FIELD: chemistry of organic compounds.
SUBSTANCE: invention relates to a method of producing (S)-2-(2-(4-hydroxyphenyl)acetamido)-3-phenylpropanoic acid of formula (II). Method includes hydrogenation of benzyl ester of (S)-2-(2-(4-hydroxyphenyl)acetamido)-3-phenylpropanoic acid (compound I) in isopropanol at temperature of 0–35 °C in presence of 0.2–20 wt % of catalyst, which is palladium applied on coal, with metal content of 5–15 %, and a hydrogen pressure of 1 to 45 atm and an optional step for cleaning the end product.
EFFECT: disclosed method enables to obtain an end product with purity higher than 99,0 %, which is suitable for use as a pharmaceutical substance in the manufacture of various types of dosage forms.
9 cl, 10 dwg, 6 tbl
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