FIELD: biochemistry.
SUBSTANCE: invention relates to an antibody or antigen-binding fragment thereof, capable of specifically binding to Sortilin and to inhibit or reduce binding of progranulin with Sortilin, as well as to a pharmaceutical composition containing said composition. Also disclosed is use of said antibody or antigen-binding fragment thereof when preparing a medicament for treating a disease, associated with decreased levels of progranulin in the patient's brain.
EFFECT: invention enables effective prevention or treatment of a disease associated with low progranulin levels in a patient's brain.
19 cl, 18 dwg, 6 tbl, 17 ex
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