FIELD: medicine; pharmaceuticals.
SUBSTANCE: The invention relates to an antibody against the 5T4 oncofoetal antigen and corresponding antibody-drug conjugates that are suitable to testing in clinical trials. The antibodies are cross-reactive for humans and cynomolgous monkeys and exhibit an affinity for human 5T4 antigen which is in the same order of magnitude as their affinity for cynomolgous 5T4 antigen. Besides, the invention relates to use of the antibodies and corresponding ADCs in the treatment of solid tumours and hematologic malignancies.
EFFECT: antibodies against 5t4 and antibody-drug conjugates are offered.
10 cl, 3 dwg, 7 tbl, 7 ex
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