FIELD: pharmaceutics.
SUBSTANCE: invention relates to ‘linker-drug’ (LD) compounds and antibody-drug conjugates (ADC) containing a non-linear self-splitting linker that can be split or converted in corresponding conditions and that reduces hydrophobicity of antibody-drug conjugate.
EFFECT: producing non-linear self-splitting linkers and their conjugates.
14 cl, 5 dwg, 2 tbl
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