FIELD: method for producing 2-methylthio-6-nitro-1,2,4-triazolo[5,1-c]-1,2,4-triazine-7-(4H)-one sodium salt dihydrate.
SUBSTANCE: invention relates to the method for producing 2-methylthio-6-nitro-1,2,4-triazolo[5,1-c]-1,2,4-triazine-7-(4H)-one sodium salt dihydrate which is characterized by carrying out two main stages: the production of a diazonium salt and the reactions of the condensation thereof with subsequent purification by hot filtration, crystallization/recrystallization and drying 2-methylthio-6-nitro-1,2,4-triazolo[5,1-c]-1,2,4-triazine-7-(4H)-one sodium salt dehydrate, with the diazonium salt being formed by diazotization of 5-amino-3-methylthio-1,2,4-triazole with polyol agent and the addition of an inorganic fluorine compound and sodium nitrite at a temperature not higher than (-5)-(-14)°C with stirring for not less than 5-20 hours and when carrying out the condensation reaction, diazotized 5-amino-3-methylthio-1,2,4-triazole is connected to the suspension of ethyl nitroacetate which is produced by mixing sodium carbonate and ethyl nitroacetate and an additionally introduced mixture of ice acetic acid and ethyl alcohol with the stages of producing the diazonium salt and carrying out condensation reactions with subsequent purification being carried out in accordance with chemical reactions.
EFFECT: technical result is a novel method for producing2-methylthio-6-nitro-1,2,4-triazolo[5,1-c]-1,2,4-triazine-7-(4H)-one sodium salt dehydrate was developed enabling to produce a product with high purity and high yield.
3 cl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF OBTAINING SODIUM SALT OF 2-METHYLTHIO-6-NITRO-1,2,4-TRIAZOLO[5,1-c]-1,2,4-TRIAZIN-7-ONE, DIHYDRATE | 2007 |
|
RU2343154C2 |
| 2-METHYLTHIO-6-NITRO-1,2,4-TRIAZOLO[5,1-C]-1,2,4-TRIAZINE-7(4H)-ONE SODIUM SALT DIHYDRATE POSSESSING ANTIVIRAL ACTIVITY | 2005 |
|
RU2294936C1 |
| SODIUM SALT OF 2-n-PROPYLTHIO-6-NITRO-1,2,4-TRIAZOLE[5,1-c]-1,2,4-TRIAZIN-7-ONE DIHYDRATE AND SODIUM SALT OF 2-n-BUTYLTHIO-6-NITRO-1,2,4-TRIAZOLE[5,1-c]-1,2,4-TRIAZIN-7-ONE DIHYDRATE | 2008 |
|
RU2402552C2 |
| SODIUM SALT OF 2-ETHYLTHIO-6-NITRO-1,2,4-TRIAZOLE[5,1-c]-1,2,4-TRIAZIN-7-ONE DIHYDRATE | 2008 |
|
RU2404182C2 |
| USE OF METHOD FOR ADMINISTRATION OF SODIUM SALT OF 2-METHYLTHIO-6-NITRO-1,2-4-TRIAZOLO[5,1-c]-1,2,4-TRIAZINE-7-ONE, DIHYDRATE, HAVING ANTIVIRAL ACTIVITY FOR TREATMENT OF CORONAVIRUS INFECTION COVID-19 | 2020 |
|
RU2774860C2 |
| METHOD OF PRODUCTION OF ANTI-VIRAL DRUG | 2017 |
|
RU2747082C2 |
| SODIUM SALT OF 2-METHYLTHIO-6-CYANO-1,2,4-TRIAZOLO[5,1-C]-1,2,4-TRIAZIN-7(4H)-ONE, TRIHYDRATE | 2015 |
|
RU2607628C1 |
| SODIUM SALT OF 3-NITRO-4-OXO-1,4-DIHYDROPYRAZOLO[5,1-c]-1,2,4-TRIAZINE-8-CARBOXYLIC ACID, DIHYDRATE | 2016 |
|
RU2641107C1 |
| SODIUM SALT OF 2-METHYL-6-FLUORO-1,2,4-TRIAZOLO[5,1-c]-1,2,4-TRIAZIN-7(4H)-ONE DIHYDRATE, HAVING ANTIVIRAL ACTIVITY | 2009 |
|
RU2493158C2 |
| 6-(2'-AMINO-2'-CARBOXYETHYLTHIO)-2-METHYLTHIO-4-PIVALOYLOXY-METHYL-1,2,4-TRIAZOLO[5,1-c] 1,2,4-TRIAZIN-7(4H)-ONE | 2011 |
|
RU2455304C1 |
