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2 741 906

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IPC

A61K31/28(2006-01-01)

A61K31/555(2006-01-01)

A61P9/10(2006-01-01)

(21) (22)

Application

2020133375, 2020-10-12

(24)

Start date

2020-10-12

(22)

Actual filing date

2020-10-12

(45)

Published

2021-01-29

(72)

Inventor

Rachin Andrei PetrovichRasulov Rizo MaksudovichBaryshok Viktor PetrovichStorozhenko Pavel ArkadevichRasulov Maksud MukhamedzhanovichZhigacheva Irina ValentinovnaKuznetsov Igor AnatolevichKorsunskaia Irina MarkovnaPiruzian Anastas LevonovichEremin Petr SerafimovichNikiforova Tatiana Ivanovna

(73)

Holder

Federalnoe Gosudarstvennoe Biudzhetnoe Uchrezhdenie Meditsinskii Issledovatelskii Tsentr Reabilitatsii I Kurortologii» Ministerstva Zdravookhraneniia Rossiiskoi Federatsii Rk» Minzdrava Rossii)

METHOD OF ATHEROGENESIS CORRECTION IN EXPERIMENT USING 1-(GERMATRAN-1-YL)-1-OXYETHYLAMINE Russian patent published in 2021 - IPC A61K31/28 A61K31/555 A61P9/10

Abstract RU 2741906 C1

FIELD: biochemistry.

SUBSTANCE: invention relates to a method for reducing the total (sum) activity of a lysosomal lipolytic enzyme, acid phospholipase A1. The method includes administering a drug, which is a composition containing 1-(germatran-1-yl)-1-hydroxyethylamine and a pharmaceutically acceptable aqueous carrier. The agent is administered to the animal intramuscularly at a dose of 5.0 mg of active substance / kg of animal weight daily for 2 months.

EFFECT: expanded methods of influencing the activity of acidic phospholipase A1 by using the agent - 1- (germatran-1-yl)-1-hydroxyethylamine, due to its newly identified biological activity, namely the ability to reduce the total activity of acidic phospholipase A1.

4 cl, 2 tbl, 1 ex

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RU 2 741 906 C1

Authors

Rachin Andrei Petrovich

Rasulov Rizo Maksudovich

Baryshok Viktor Petrovich

Storozhenko Pavel Arkadevich

Rasulov Maksud Mukhamedzhanovich

Zhigacheva Irina Valentinovna

Kuznetsov Igor Anatolevich

Korsunskaia Irina Markovna

Piruzian Anastas Levonovich

Eremin Petr Serafimovich

Nikiforova Tatiana Ivanovna

Dates

2021-01-29—Published

2020-10-12—Filed