VECTORS OF FVIII FACTOR BASED ON ADENO-ASSOCIATED VIRUSES, CORRESPONDING VIRUS PARTICLES AND THERAPEUTIC COMPOSITIONS CONTAINING THEM Russian patent published in 2021 - IPC A61K39/12 C07K14/755 

FIELD: biotechnology.

SUBSTANCE: described is a group of inventions comprising a pharmaceutical composition for treating haemophilia A, comprising a recombinant virus AAB5-FVIII-SQ in a concentration of about 1E12 vg/ml to about 2E14 vg/ml, method of treating a subject suffering from hemophilia A, a method for reducing bleeding time in a haemorrhage episode in a subject suffering from haemophilia A, a method for increasing expression of factor VIII protein in a subject, method of treating a subject suffering from hemophilia A, comprising steps of determining the absence of antibodies to the AACB capsid in the serum of said subject and administering the above pharmaceutical composition, and a method of treating a subject suffering from hemophilia A, comprising the steps of administering to said subject a pharmaceutical composition and, after administering said pharmaceutical composition, determining the absence or presence of the antibodies to the AACB capsid in the serum of said subject.

EFFECT: invention extends the range of products for treating haemophilia A.

26 cl, 49 dwg, 1 tbl, 8 ex