PDE4 INHIBITOR Russian patent published in 2021 - IPC C07D471/04 C07D498/04 A61K31/519 A61P29/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof:

where X is selected from O, N(R₃), -CH(R₃)-; R₃ is selected from H, COOH, R₄-L₁- or selected from a group, consisting of C_1-6alkyl, C_1-6heteroalkyl, C_3-6cycloalkyl and phenyl, each of which is optionally substituted with 1, 2 or 3 R; "hetero" in C_1-6heteroalkyl is selected from -O-, -C(=O)O- and -S(=O)₂; R₄ is selected from a group consisting of phenyl and 5–6-member heteroaryl, each of which is optionally substituted with 1 or 2 R; "hetero" in 5–6-member heteroaryl is selected from -NH-; L 1 is selected from -CH₂-; each of R₁ and R₂ is independently selected from H, F, Cl, Br, I, OH, CN, NH₂, R₅-L₂- or selected from a group consisting of C_1-6alkyl, C_1-6alkoxy, C_2-6alkenyl, 3–6 membered heterocycloalkenyl, C_3-6cycloalkyl, phenyl, and 5–6-membered heteroaryl, each of which is optionally substituted with 1, 2 or 3 R; "hetero" in 3–6-member heterocycloalkenyl is selected from -NH- and -C(=O)-; "hetero" in 5–6-member heteroaryl is selected from -NH- and -S-; R₅ is selected from a group consisting of phenyl and 5–6-member heteroaryl, each of which is optionally substituted with 1, 2 or 3 R; "hetero" in 5–6-member heteroaryl is selected from -NH-; L₂ is selected from -CH₂- and O; R₆ is selected from C_1-3alkyl, which is optionally substituted with 1, 2 or 3 R; R is selected from H, halogen, OH, NH₂, CN or is selected from a group consisting of C_1-6alkyl and C_1-6 heteroalkyl, each of which is optionally substituted with 1, 2 or 3 R'; "hetero" in C_1-6heteroalkyl is selected from -O- and -C(=O)O-; R' is selected from F, Me, which is a PDE4 inhibitor, as well as its use in preparing a drug preparation for treating PDE4-related diseases.

EFFECT: disclosed is a PDE4 inhibitor.

30 cl, 11 tbl, 78 ex