LSD1 INHIBITOR, AS WELL AS ITS PRODUCTION METHOD AND ITS APPLICATION Russian patent published in 2022 - IPC C07D207/09 C07D211/18 C07D217/26 C07D249/06 C07D257/04 C07D263/56 C07D271/06 C07D413/04 C07D417/04 C07D471/04 C07D487/04 A61K31/13 A61K31/135 A61K31/165 A61P35/00 

Abstract RU 2763898 C2

FIELD: medicine.

SUBSTANCE: present invention relates to a class of cyclopropylamine compounds, namely to a compound of the formula (I), its pharmaceutically acceptable salt or its tautomer,

where values of f, r, e, p, m, n, R1, R2, R3, R4 and R6 are such as defined in the formula of the invention. Pharmaceutical compositions and the use of a compound of the formula (I) in the manufacture of LSD1 inhibitors and a drug for the treatment of lung cancer are also proposed.

EFFECT: obtaining new organic compounds that are inhibitors of lysin-specific demethylase 1 (LSD1).

29 cl, 8 tbl, 246 ex

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RU 2 763 898 C2

Authors

Wu, Lingyun

Zhang, Li

Zhao, Lele

Sun, Jianjun

Chen, Zhaoguo

Li, Jian

Chen, Shuhui

Dates

2022-01-11Published

2018-01-24Filed