METHOD FOR PREVENTION OF ULCERATION OF GASTRIC MUCOSA Russian patent published in 2021 - IPC A61K31/00 A61K31/196 A61K47/12 A61K47/36 A61P1/04 

FIELD: medicine.

SUBSTANCE: invention relates namely to a method for the prevention of ulceration on the gastric mucosa, comprising oral administration of a homogeneous gel containing chitosan to rats, in which the gel is used in doses from 0.08 to 0.24 ml / 100 g of rat body weight once 1 hour before exposure to ulcerogenic factor diclofenac sodium at a dose of 50 mg / kg, while 100 ml of gel includes 1 g of high molecular weight chitosan with a molecular weight of 500-1000 kDa, 0.25 ml of glacial acetic acid, 99 ml of water.

EFFECT: present invention provides the development of a method for the prevention of ulceration on the gastric mucosa, which, when taking a gel containing chitosan at a dose of 0.08-0.24 ml / 100 g of body weight one hour before the administration of the ulcerogenic agent diclofenac sodium at a dose of 50 mg / kg, reduces the number of ulcers by 7-20.4%, the area of ​​ulcers by 25.0% -74.2%, and, exhibits antiulcer activity (the ratio of the Pauls index of the control group to the Pauls index of the experimental group), equal to 1.33-3.87, respectively.

1 cl, 1 ex, 3 dwg