FIELD: medicine.
SUBSTANCE: invention relates to medicine and relates to a method for the prevention of ulceration on the gastric mucosa, including the oral administration of a homogeneous gel containing chitosan, where the gel is used at a dose of 0.16 ml/100 g of body weight once 1 hour before exposure to the ulcerogenic factor diclofenac sodium at a dose of 50 mg/kg, while 100 ml of gel includes 1 g of high molecular weight chitosan with a molecular weight of 500-700 kDa and a degree of deacetylation of 80%, 0.437 g of dexpanthenol, 0.25 ml of glacial acetic acid and water up to 100 ml. The invention provides a decrease in the number of ulcers by 15.0%, the area of ulcers by 62.9%.
EFFECT: improvement of method for the prevention of ulceration on the gastric mucosa.
1 cl, 1 ex, 3 dwg
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Authors
Dates
2021-11-15—Published
2021-02-24—Filed