TREATMENT OF HEPATIC STEATOSIS RELATED OLIGO-OVULATION Russian patent published in 2021 - IPC A61K31/585 A61K31/155 A61K31/4439 A61P1/16 A61P43/00 

FIELD: pharmaceutics.

SUBSTANCE: set of inventions relates to pharmaceutics and medicine, and specifically to the use of a pharmaceutical combination containing spironolactone, pioglitazone and metformin, to a method for preventing or treating polycystic ovarian syndrome and a method for preventing or treating low ovulation rates relating to hepatic steatosis in adolescent girls or women of childbearing age. A combination of spironolactone, pioglytopon and metformin, taken in certain quantities, is used for the prevention or treatment of polycystic ovary syndrome, for the prophylaxis or treatment of low ovulation rate relating to hepatic steatosis n adolescent girls or women of childbearing age, as well as for the manufacture of a pharmaceutical form of delivery. Treatment methods include the daily combined administration of spironolactone, pioglitazone and metformin in specified quantities.

EFFECT: set of inventions provides for the effective treatment of polycystic ovaries, the reduction of visceral and hepatic fat in adolescent girls or women of childbearing age and the long-term normalization of the ovulation rate after treatment.

51 cl, 5 tbl, 2 ex, 7 dwg