FIELD: biotechnology.
SUBSTANCE: options of a human antibody that immuno-specifically bind to human IL-5 are proposed. Nucleic acid, an expression vector, and a cell for expressing antibodies according to the invention are also proposed. Besides, the invention relates to the use of the specified antibodies and pharmaceutical compositions containing them for the treatment of eosinophilic asthma, hypereosinophilic syndrome, nasal polyposis with eosinophilic lesion, eosinophilic granulomatosis with polyangiitis, atopic dermatitis or eosinophilic esophagitis. Antibody molecules can bind to human IL-5 with an equilibrium affinity constant (KD) of at least about 40 pM that is determined by surface plasmon resonance.
EFFECT: obtaining anti-IL-5 antibodies.
20 cl, 24 dwg, 15 tbl
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