ANTI-IL-5 ANTIBODIES Russian patent published in 2021 - IPC C07K16/24 C12N5/10 C12N15/13 C12N15/63 A61K39/395 A61P11/00 

Abstract RU 2758008 C2

FIELD: biotechnology.

SUBSTANCE: options of a human antibody that immuno-specifically bind to human IL-5 are proposed. Nucleic acid, an expression vector, and a cell for expressing antibodies according to the invention are also proposed. Besides, the invention relates to the use of the specified antibodies and pharmaceutical compositions containing them for the treatment of eosinophilic asthma, hypereosinophilic syndrome, nasal polyposis with eosinophilic lesion, eosinophilic granulomatosis with polyangiitis, atopic dermatitis or eosinophilic esophagitis. Antibody molecules can bind to human IL-5 with an equilibrium affinity constant (KD) of at least about 40 pM that is determined by surface plasmon resonance.

EFFECT: obtaining anti-IL-5 antibodies.

20 cl, 24 dwg, 15 tbl

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RU 2 758 008 C2

Authors

Liddament, Mark Terens

Dojl, Entoni

Klark, Adam

Lejn, Devid Khose Sajmon

Kuksi, Bridzhit Enn

Dates

2021-10-25Published

2017-12-20Filed