FIELD: biotechnology.
SUBSTANCE: disclosed is a method for preventing, treating or relieving a complement-mediated disorder associated with C3b complement feedback cycle hyperactivity in a patient, and a pharmaceutical composition and a kit for implementing said method are also disclosed. Also described are recombinant viral vectors encoding factor I, recombinant viral particles encapsulating these vectors, and their use in methods of treatment.
EFFECT: invention provides a significant increase in the level of factor I in plasma, which leads to achieving a systemic increase in the level of C3b-inactivating and iC3b-degrading activity in the patient.
44 cl, 9 dwg, 2 tbl, 2 ex
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