FIELD: biotechnology; virology.
SUBSTANCE: methods for serotyping and/or determination of heterogeneity of a viral particle are described, using the determination of weight, in particular, using liquid chromatography/mass-spectrometry (LC/MS) or liquid chromatography/mass-spectrometry-mass-spectrometry (LC/MS/MS). Methods for the improvement of rAAV particle stability, improvement of rAAV particle assembly in a cell or improvement of rAAV particle transduction in a cell are also described, using an increase in a degree of acetylation and/or deamidation of capsid proteins. The group of inventions also relates to capsid AAV protein for the production of AAV particle and a recombinant AAV particle, a pharmaceutical composition, a kit and a product for the delivery of nucleic acid to a host cell.
EFFECT: group of inventions allows for improvement of methods for characterizing viral particles.
64 cl, 30 dwg, 11 tbl, 5 ex
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