ANTIBODY FORMULATIONS Russian patent published in 2022 - IPC A61K39/395 A61P19/02 C07K16/28 

FIELD: medicine; immunology.

SUBSTANCE: group of inventions is intended for treating a disease mediated by type 5 CXC chemokine receptor. Antibody formulation suitable for subcutaneous administration to a patient and used for treating type 5 CXC chemokine receptor mediated disease, contains an antibody, a citrate buffer, polysorbate 20 or polysorbate 80, arginine and sucrose. Components are used in the declared amounts, and the pH value of the composition is approximately 6. Antibody is a fully human anti-CXCR5 antibody, containing a heavy chain with the amino acid sequence SEQ ID NO: 33 and light chain with amino acid sequence SEQ ID NO: 32. In other embodiments, containers and kits comprising said composition are provided. Also disclosed is a method of treating rheumatoid arthritis, involving administering to a subject in need thereof a therapeutically effective amount of said antibody composition.

EFFECT: use of the group of the invention provides prolonged stability of the antibody formulations during storage in glass containers.

13 cl, 9 tbl, 2 ex, 20 dwg