FIELD: pharmacology.
SUBSTANCE: invention relates to a preparation for treatment of receptor-mediated chemokine C-X-C type 5 (CXCR5) diseases. The drug contains approximately 5 mg/ml to approximately 100 mg/ml of IgG4 antibody that binds to the chemokine C-X-C type 5 receptor (CXCR5) and approximately 5 to approximately 50 mM of citrate as a buffer. The pH of the preparation is at or below the pH value of about 6, as well as the pI of the antibody.
EFFECT: obtaining of a stable preparation that can be used for treatment of chemokine C-X-C type 5 receptor mediated diseases.
9 cl, 38 dwg, 117 tbl, 21 ex
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Authors
Dates
2018-02-08—Published
2013-03-26—Filed