FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically to fused proteins based on TGF-beta receptor; it can be used in medicine for the treatment of PD-L1-mediated tumor. Bifunctional fused protein is proposed, containing a targeting part – an antibody against PD-L1 and extracellular domain TGF-beta RII.
EFFECT: invention provides for obtaining fused proteins that are specific relatively to binding to human TGF-beta1 and PD-L1, block binding to PD-1 and inhibit TGF-bets-induced pSMAD3 activity, as well as show a higher expression level and a stable structure compared to fused protein of the similar structure based on uncut ECD TGF-beta RII.
19 cl, 8 dwg, 10 tbl, 12 ex
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