FIELD: biochemistry.
SUBSTANCE: invention relates to an antibody or its antigen-binding fragment that specifically binds to human CD3. Also a single chain antibody that specifically binds to human CD3; a bispecific antibody that specifically binds to human CD3; a pharmaceutical composition containing the said antibodies; an isolated nucleic acid molecule encoding the said antibody; a recombinant vector; and a host cell containing the said nucleic acid molecule are disclosed. A method of producing of the said antibody is disclosed.
EFFECT: invention makes it possible to effectively treat diseases associated with CD3.
14 cl, 8 ex, 17 tbl, 11 dwg
| Title |
Year |
Author |
Number |
| BISPECIFIC PROTEIN |
2019 |
- Cao Zhuoxiao
- Luo Xiao
- He Ning
- Hu Qiyue
- Zhang Lianshan
- Tao Weikang
|
RU2784486C1 |
| ANTIBODY TO PD-1, ITS ANTIGEN-BINDING FRAGMENT AND ITS PHARMACEUTICAL USE |
2020 |
- Gu Xiaoling
- Ye Xin
- Ge Hu
- Tao Weikang
|
RU2807484C2 |
| CONNECTIVE TISSUE GROWTH FACTOR ANTIBODY AND USE THEREOF |
2020 |
- Fu, Yayuan
- Ma, Syaoli
- Ge, Khu
- Tao, Vejkan
|
RU2819228C2 |
| ANTI-CLAUDIN 18.2 ANTIBODY AND USE THEREOF |
2020 |
- Yan, Yan
- Ge, Khu
- Tao, Vejkan
|
RU2822550C2 |
| PHARMACEUTICAL COMPOSITION CONTAINING ANTIBODIES TO PCSK-9, AND ITS USE |
2018 |
- Tian, Chenmin
- Li, Hao
- Liu, Xun
|
RU2782792C2 |
| ANTIBODY AGAINST B7-H3, ITS ANTIGEN-BINDING FRAGMENT AND THEIR MEDICAL USE |
2018 |
- Gu, Tszinmin
- Van, Syaokhua
- E, Sin
- Yan, Lyutsin
- Chzhan, Tin
- Tao, Vejkan
- Chzhan, Lyanshan
|
RU2765306C2 |
| PHARMACEUTICAL COMPOSITION CONTAINING ANTI-IL-5 ANTIBODY, AND USE THEREOF |
2020 |
- U, Tintin
- Li, Khao
- Lyu, Syun
- Tao, Vejkan
|
RU2824390C2 |
| FUSED PROTEIN CONTAINING TGF-BETA RECEPTOR, AND ITS PHARMACEUTICAL USE |
2018 |
- Gu, Tszinmin
- Lo, Syao
- Tao, Vejkan
|
RU2776204C1 |
| CONJUGATE OF ANTI-CLAUDIN ANTIBODY AND MEDICINAL AGENT AND PHARMACEUTICAL USE THEREOF |
2020 |
- Yang Yang
- Xu Jianyan
- Tao Weikang
|
RU2826119C1 |
| PHARMACEUTICAL COMPOSITION OF THE FUSION PROTEIN OF THE TRANSFORMING GROWTH FACTOR BETA RECEPTOR AND ITS APPLICATION |
2019 |
- Tyan, Chenmin
- Li, Khao
- Lyu, Syun
|
RU2791683C2 |
