FIELD: experimental medicine.
SUBSTANCE: when the left hemisphere of the brain in experimental animals is disconnected, amtizol is administered intraperitoneally at an equimolar dose of 25 mg/kg 30 minutes before a hypoxic episode. When both hemispheres are disconnected, 2-aminobenzothiazole is administered intraperitoneally at an equimolar dose of 32.5 mg/kg 30 minutes before a hypoxic episode. When the right hemisphere of the brain is disconnected, 2-amino-4-acetylthiazolo[5,4-b]indole (VM-606) is administered intraperitoneally at an equimolar dose of 50 mg/kg 30 minutes before a hypoxic episode.
EFFECT: method allows extending the life expectancy of an animal in an experiment in hypercapnic hypoxia by using antihypoxants of various structures.
1 cl, 2 tbl, 2 dwg
| Title |
Year |
Author |
Number |
| USE OF 2-AMINO-7-BROMO-4-ACETYLAZO[5,4-b]INDOL TO PROTECT ORGANISM AGAINST HYPERBARIC AND HEMATIC HYPOXIA AND/OR LIVER AGAINST CARBON TETRACHLORIDE POISONING |
2004 |
- Marysheva Vera Vasil'Evna
- Shabanov Petr Dmitrievich
- Gavrev Aleksej Ivanovich
|
RU2318828C2 |
| APPLICATION OF 7-BROMOMIDAZO [4,5-B] INDOLE-2-THYONE FOR PROTECTION OF ORGANISM AGAINST INFLUENCE OF HYPOBARIC, HEMIC AND HYPERCAPNIC HYPOXIA |
2005 |
- Marysheva Vera Vasil'Evna
- Shabanov Petr Dmitrievich
|
RU2340341C2 |
| APPLICATION OF 7-BROMINE-4-ACETYLMIDAZO[4,5-b]INDOLE-2-THIONE FOR PROTECTION AGAINST HYPOBARIC AND HYPERCAPNIC HYPOXIA |
2005 |
- Marysheva Vera Vasil'Evna
- Shabanov Petr Dmitrievich
- Makeev Boris Lavrovich
- Klochkov Valentin Timofeevich
|
RU2335285C2 |
| 2-AMINO-4-ACETYLTHIAZOLO[5,4-B]INDOLE PROTECTING BODY FROM EFFECT OF HYPOXIA AND TOXIC LUNG EDEMA |
2000 |
- Marysheva V.V.
- Shabanov P.D.
- Torkunov P.A.
- Zemljanoj A.V.
- Varlashova M.B.
|
RU2188824C1 |
| USE OF 2-AMINO-4-ACETYLTHIAZOLO[5,4-b]INDOLE HYDROBROMIDE FOR BODY PROTECTION AGAINST EFFECT OF HEMIC AND HYPERCAPNIC HYPOXIA |
2003 |
- Marysheva Vera Vasil'Evna
- Shabanov Petr Dmitrievich
|
RU2281095C2 |
| METHOD FOR INCREASING BODY RESISTANCE TO ACUTE HYPOXIA IN EXPERIMENT |
2013 |
- Novikov Vasilij Egorovich
- Levchenkova Ol'Ga Sergeevna
|
RU2517032C1 |
| 4-ACETYLTHIAZOLO[5,4-b]INDOL-2-SUCCINIMIDE PROTECTING BODY AGAINST HYPOXIA AND POSSESSING PROPHYLACTIC EFFECT IN LUNG TOXIC EDEMA |
2004 |
- Marysheva Vera Vasil'Evna
- Torkunov Pavel Anatol'Evich
- Shabanov Petr Dmitrievich
|
RU2281950C2 |
| 7-BROMO-4-ACETYLTHIAZOLO[5,4-b]INDOL-2-SUCCINIMIDE PROTECTING BODY AGAINST HYPOXIA AND POSSESSING CURATIVE EFFECT IN LUNG TOXIC EDEMA |
2004 |
- Marysheva Vera Vasil'Evna
- Torkunov Pavel Anatol'Evich
- Shabanov Petr Dmitrievich
|
RU2281951C2 |
| APPLICATION OF 4-ACETYL-7-BROMINE-8b-HYDROXY-3a,8b-DIHYDROIMIDAZO {4,5-b}INDOLE-2-THIONE FOR PROTECTION OF ORGANISM AGAINST IMPACT OF HYPOBARIC AND GEMIC HYPOXIA |
2005 |
- Marysheva Vera Vasil'Evna
- Shabanov Petr Dmitrievich
|
RU2335286C2 |
| DRUG POSSESSING ACTOPROTECTIVE, ANTIHYPOXIC, NEUROPROTECTIVE, ANTIAMNESTIC AND THERMOPROTECTIVE ACTIVITY |
2011 |
- Tsublova Elena Gennad'Evna
- Jasnetsov Viktor Vladimirovich
- Skachilova Sof'Ja Jakovlevna
- Jasnetsov Vladimir Viktorovich
|
RU2460529C1 |
